Titan announces positive Phase III results for probuphine in Opioid addiction

Titan Pharmaceuticals have announced positive, statistically significant results from its phase III clinical trial of Probuphine in the treatment of opioid addiction.

FDA lift clinical hold on Adolors Entereg (alvimopan) program for chronic opioid bowel dysfunction (OBD).

FDA lift clinical hold on Adolors Entereg (alvimopan) program for chronic opioid bowel dysfunction (OBD).

EU approves Relistor for Opioid-Induced Constipation In Advanced Illness Patients

Wyeth and Progenics have received marketing approval for Relistor (methylnaltrexone bromide) subcutaneous injection in the EU for the treatment of opioid-induced constipation in advanced illness patients who are receiving palliative care when response to usual laxative therapy has not been sufficient.

Researchers from the Hungary publish series of mu opioid Endomorphins

In this week’s JMC Researchers from the Hungary publish series of mu opioid Endomorphins

Wyeth publish data on Relistor Phase III trials in Opioid induced Constipation

Results from a pivotal phase 3 trial of Relistor (methylnaltrexone bromide) subcutaneous injection have been publsihed in the in the May 29, 2008 issue of the New England Journal of Medicine. Results show that patients receiving Relistor had significantly more bowel movements within four hours of receiving their first dose than patients receiving [...]

Wyeth and Progenics present data on Relistor (Methylnaltrexone) for opioid-induced constipation

Phase II data presented by Wyeth and Progenics on Relistor (Methylnaltrexone) in the treatment of opioid-induced constipation shows the oral formulation to significantly improve bowel activity in patients receiving opioids for pain management
The IV formulation did not show efficacy in Phase III trials of post-operative ileus

Entereg (alvimopan) approved for management of postoperative ileus

The FDA today approved Adolor’s Opioid mu antagonist Entereg (alvimopan) for management of postoperative ileus